One hundred ninety-two patients with CAP were randomized to receive oral nemonoxacin (500Â mg or 750Â mg) or levofloxacin (500Â mg) once daily for 7-10Â days. To compare the clinical efficacy and safety of nemonoxacin with levofloxacin in treating community-acquired pneumonia (CAP) in a Phase II clinical trial. Liu, Yang Zhang, Yingyuan Wu, Jufang Zhu, Demei Sun, Shenghua Zhao, Li Wang, Xuefeng Liu, Hua Ren, Zhenyi Wang, Changzheng Xiu, Qingyu Xiao, Zuke Cao, Zhaolong Cui, Shehuai Yang, Heping Liang, Yongjie Chen, Ping Lv, Yuan Hu, Chengping Lv, Xiaoju Liu, Shuang Kuang, Jiulong Li, Jianguo Wang, Dexi Chang, Liwen Pharmacokinetic/pharmacodynamic integration revealed significantly higher values for Cmax/MIC and AUC/MIC ratios in renal damaged ducks than in healthy ones, indicating the excellent pharmacokinetic characteristics of levofloxacin in renal damaged ducks.Ī randomized, double-blind, multicenter Phase II study comparing the efficacy and safety of oral nemonoxacin with oral levofloxacin in the treatment of community-acquired pneumonia. Also, the dose of levofloxacin should be reduced in renal damaged ducks. Oral administration of levofloxacin at 10â€‰mgâ€‰kgâˆ’1â€‰bwt may be highly efficacious against susceptible bacteria in ducks.

The pharmacokinetic profile of levofloxacin is altered in renal damaged ducks due to the increased serum levofloxacin concentrations compared with that in clinically healthy ducks. The drug was eliminated (t1/2(el at a significant slower rate (3.94â€‰h in renal damaged than in healthy ducks (2.89â€‰h. Following PO administration, the peak serum concentration (Cmax was higher in renal damaged than in healthy ducks and was achieved at maximum time (tmax of 2.47 and 2.05â€‰h, respectively. Total clearance (Cltot in renal damaged ducks (0.20â€‰Lâ€‰kgâˆ’1â€‰hâˆ’1 was significantly lower as compared to that in healthy ones (0.41â€‰Lâ€‰kgâˆ’1â€‰hâˆ’1. Following IV administration, elimination half-life (t1/2(Î² and mean residence time (MRT were longer in renal damaged ducks than in healthy ones. Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administrationĭirectory of Open Access Journals (Sweden)įull Text Available The pharmacokinetics aspects of levofloxacin were studied in healthy and experimentally renal damaged Muscovy ducks after single intravenous (IV and oral (PO dose of 10â€‰mgâ€‰kgâˆ’1â€‰bwt.

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